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RM 2,404+ Direct flights from Panama City

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 28/4. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
PTY — KUL
29 Mar — 5 Apr1
1 adult
1 adult, Economy, 0 bags

Direct flights from Panama City

Enter your travel dates to find the best prices.

Cheapest flights from Panama City
Explore the most affordable flight options available from Panama City. Find the lowest fares based on data from user searches, with prices last updated on 27 February 2026.

Mon 27/420:25
PTY
-
MAD
Nonstop9h 50m
Air Europa
Sun 17/515:05
MAD
-
PTY
Nonstop10h 35m
Air Europa
Deal found 24/2RM 2,679
Mon 4/520:25
PTY
-
MAD
Nonstop9h 50m
Air Europa
Sat 16/515:05
MAD
-
PTY
Nonstop10h 35m
Air Europa
Deal found 25/2RM 2,718
Tue 31/320:25
PTY
-
MAD
Nonstop9h 50m
Air Europa
Tue 14/415:05
MAD
-
PTY
Nonstop10h 35m
Air Europa
Deal found 27/2RM 2,726
Mon 27/420:25
PTY
-
MAD
Nonstop9h 50m
Air Europa
Fri 15/515:05
MAD
-
PTY
Nonstop10h 35m
Air Europa
Deal found 24/2RM 2,737
Mon 4/520:25
PTY
-
MAD
Nonstop9h 50m
Air Europa
Fri 15/515:05
MAD
-
PTY
Nonstop10h 35m
Air Europa
Deal found 25/2RM 2,780
Wed 29/420:25
PTY
-
MAD
Nonstop9h 50m
Air Europa
Wed 20/515:05
MAD
-
PTY
Nonstop10h 35m
Air Europa
Deal found 24/2RM 2,804
Tue 2/620:25
PTY
-
MAD
Nonstop9h 50m
Air Europa
Thu 11/615:05
MAD
-
PTY
Nonstop10h 35m
Air Europa
Deal found 24/2RM 2,823
Sun 10/520:25
PTY
-
MAD
Nonstop9h 50m
Air Europa
Sat 16/515:05
MAD
-
PTY
Nonstop10h 35m
Air Europa
Deal found 24/2RM 2,842
Thu 23/420:25
PTY
-
MAD
Nonstop9h 50m
Air Europa
Mon 4/515:05
MAD
-
PTY
Nonstop10h 35m
Air Europa
Deal found 23/2RM 2,866
Wed 6/520:25
PTY
-
MAD
Nonstop9h 50m
Air Europa
Tue 19/515:05
MAD
-
PTY
Nonstop10h 35m
Air Europa
Deal found 24/2RM 2,904

Find direct flights from Panama City within your budget

 
Use the slider to find direct flights from Panama City within your budget. Price data is based on user searches made on Cheapflights. Over the past seven days, Cheapflights users made 407,431 searches. This data was last updated on 27 February 2026.

Fly to

Route

Departure

Return

Price

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Tue 31/3

20:25-13:15

Nonstop9h 50m

Madrid Barajas

Tue 14/4

15:05-18:40

Nonstop10h 35m

RM 2,726

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Mon 4/5

20:25-13:15

Nonstop9h 50m

Madrid Barajas

Fri 29/5

15:05-18:40

Nonstop10h 35m

RM 2,947

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Mon 4/5

20:25-13:15

Nonstop9h 50m

Madrid Barajas

Wed 6/5

15:05-18:40

Nonstop10h 35m

RM 2,967

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Wed 15/4

20:25-13:15

Nonstop9h 50m

Madrid Barajas

Thu 30/4

15:05-18:40

Nonstop10h 35m

RM 3,180

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Tue 14/4

20:25-13:15

Nonstop9h 50m

Madrid Barajas

Wed 29/4

15:05-18:40

Nonstop10h 35m

RM 3,452

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Tue 10/3

21:30-13:05

Nonstop9h 35m

Madrid Barajas

Thu 19/3

15:10-19:45

Nonstop10h 35m

RM 3,506

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Wed 22/4

20:25-13:15

Nonstop9h 50m

Madrid Barajas

Sat 19/9

15:05-18:40

Nonstop10h 35m

RM 3,611

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Thu 30/4

20:25-13:15

Nonstop9h 50m

Madrid Barajas

Sat 30/5

15:05-18:40

Nonstop10h 35m

RM 3,634

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Wed 6/5

20:25-13:15

Nonstop9h 50m

Madrid Barajas

Thu 14/5

15:05-18:40

Nonstop10h 35m

RM 3,840

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Thu 23/7

20:25-13:15

Nonstop9h 50m

Madrid Barajas

Mon 10/8

15:05-18:40

Nonstop10h 35m

RM 3,933

Flights are sorted by cheapest return flights first.

Deals found on 24/2

Showing 1-10 of 22 resultsSorted by cheapest first
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Estimated return price
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