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RM 2,625+ Direct flights from Panama City

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/3. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
PTY — KUL
1 Nov — 8 Nov1
1 adult
1 adult, Economy

Direct flights from Panama City

Enter your travel dates to find the best prices.

Cheapest flights from Panama City
Explore the most affordable flight options available from Panama City. Find the lowest fares based on data from user searches, with prices last updated on 2 October 2025.

Mon 3/1121:30PTY - MAD
Nonstop9h 35mAir Europa
Fri 21/1115:10MAD - PTY
Nonstop10h 35mAir Europa
Deal found 1/10RM 2,818
Thu 6/1121:30PTY - MAD
Nonstop9h 35mAir Europa
Fri 14/1115:10MAD - PTY
Nonstop10h 35mAir Europa
Deal found 1/10RM 2,923
Mon 3/1121:30PTY - MAD
Nonstop9h 35mAir Europa
Sun 23/1115:10MAD - PTY
Nonstop10h 35mAir Europa
Deal found 1/10RM 2,927
Fri 5/1221:30PTY - MAD
Nonstop9h 35mAir Europa
Fri 12/1215:10MAD - PTY
Nonstop10h 35mAir Europa
Deal found 29/9RM 3,016
Tue 4/1121:30PTY - MAD
Nonstop9h 35mAir Europa
Sun 16/1115:10MAD - PTY
Nonstop10h 35mAir Europa
Deal found 1/10RM 3,033
Sat 7/221:30PTY - MAD
Nonstop9h 35mAir Europa
Sun 15/215:10MAD - PTY
Nonstop10h 35mAir Europa
Deal found 1/10RM 3,049
Tue 28/1021:30PTY - MAD
Nonstop9h 35mAir Europa
Fri 14/1115:10MAD - PTY
Nonstop10h 35mAir Europa
Deal found 30/9RM 3,142
Sun 8/221:30PTY - MAD
Nonstop9h 35mAir Europa
Thu 19/215:10MAD - PTY
Nonstop10h 35mAir Europa
Deal found 1/10RM 3,184
Thu 4/1221:30PTY - MAD
Nonstop9h 35mAir Europa
Fri 12/1215:10MAD - PTY
Nonstop10h 35mAir Europa
Deal found 29/9RM 3,230
Mon 3/1121:30PTY - MAD
Nonstop9h 35mAir Europa
Thu 13/1115:10MAD - PTY
Nonstop10h 35mAir Europa
Deal found 1/10RM 3,306
Thu 5/221:30PTY - MAD
Nonstop9h 35mAir Europa
Fri 13/215:10MAD - PTY
Nonstop10h 35mAir Europa
Deal found 1/10RM 3,319

Find direct flights from Panama City within your budget

 
Use the slider to find direct flights from Panama City within your budget. Price data is based on user searches made on Cheapflights. Over the past seven days, Cheapflights users made 407,431 searches. This data was last updated on 2 October 2025.

Fly to

Kuala Lumpur Intl

Route

Departure

Return

Price

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Sun 9/11

21:30-13:05

Nonstop9h 35m

Madrid Barajas

Tue 18/11

15:10-19:45

Nonstop10h 35m

RM 2,923

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Thu 20/11

21:30-13:05

Nonstop9h 35m

Madrid Barajas

Fri 28/11

15:10-19:45

Nonstop10h 35m

RM 2,923

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Thu 6/11

21:30-13:05

Nonstop9h 35m

Madrid Barajas

Fri 14/11

15:10-19:45

Nonstop10h 35m

RM 2,923

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Mon 17/11

21:30-13:05

Nonstop9h 35m

Madrid Barajas

Mon 24/11

15:10-19:45

Nonstop10h 35m

RM 2,923

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Sat 8/11

21:30-13:05

Nonstop9h 35m

Madrid Barajas

Fri 21/11

15:10-19:45

Nonstop10h 35m

RM 2,923

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Tue 11/11

21:30-13:05

Nonstop9h 35m

Madrid Barajas

Tue 18/11

15:10-19:45

Nonstop10h 35m

RM 2,923

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Sat 8/11

21:30-13:05

Nonstop9h 35m

Madrid Barajas

Sun 23/11

15:10-19:45

Nonstop10h 35m

RM 3,033

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Tue 4/11

21:30-13:05

Nonstop9h 35m

Madrid Barajas

Thu 20/11

15:10-19:45

Nonstop10h 35m

RM 3,033

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Fri 7/11

21:30-13:05

Nonstop9h 35m

Madrid Barajas

Sun 23/11

15:10-19:45

Nonstop10h 35m

RM 3,033

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Tue 11/11

21:30-13:05

Nonstop9h 35m

Madrid Barajas

Thu 20/11

15:10-19:45

Nonstop10h 35m

RM 3,306

Flights are sorted by cheapest return flights first.

Deals found on 30/9

Showing 1-10 of 23 results
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Best time to book a flight from Panama City

Have a flexible travel schedule? Discover the best time to fly from Panama City with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Access useful and relevant information related to your journey from Panama City. This can include details such as airport transportation, visa requirements, travel insurance, luggage regulations, and any other information that can ensure a smooth and hassle-free travel experience. Please note that the information is based on general guidance and may need to be verified with official sources. Data last updated 2 October 2025.

  • Where can you fly direct from Panama City?

    Currently, the most popular direct flight destination from Panama City is Montego Bay.

  • What is the best time of year to fly direct from Panama City?

    If you're seeking the lowest price on a direct flight from Panama City, March is worth consideration as prices are at their lowest, on average. In terms of the number of daily non-stop flights, March offers travelers the most options.

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