Find flights
Deals

RM 2,619+ Direct flights from Panama City

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 31/12. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
PTY — KUL
5 Dec — 12 Dec1
1 adult
1 adult, Economy, 0 bags

Direct flights from Panama City

Enter your travel dates to find the best prices.

Cheapest flights from Panama City
Explore the most affordable flight options available from Panama City. Find the lowest fares based on data from user searches, with prices last updated on 5 November 2025.

Wed 15/420:25PTY - MAD
Nonstop9h 50mAir Europa
Thu 30/415:05MAD - PTY
Nonstop10h 35mAir Europa
Deal found 3/11RM 3,030
Wed 29/420:25PTY - MAD
Nonstop9h 50mAir Europa
Sun 10/515:05MAD - PTY
Nonstop10h 35mAir Europa
Deal found 4/11RM 3,042
Wed 4/321:30PTY - MAD
Nonstop9h 35mAir Europa
Sun 15/315:10MAD - PTY
Nonstop10h 35mAir Europa
Deal found 4/11RM 3,177
Sat 22/1118:20PTY - MAD
Nonstop10h 05mIberia
Sat 14/211:40MAD - PTY
Nonstop11h 05mIberia
Deal found 3/11RM 3,198
Sat 7/321:30PTY - MAD
Nonstop9h 35mAir Europa
Tue 17/315:10MAD - PTY
Nonstop10h 35mAir Europa
Deal found 4/11RM 3,311
Sun 7/1221:30PTY - MAD
Nonstop9h 35mAir Europa
Wed 31/1215:10MAD - PTY
Nonstop10h 35mAir Europa
Deal found 4/11RM 3,366
Sun 15/221:30PTY - MAD
Nonstop9h 35mAir Europa
Sat 28/215:10MAD - PTY
Nonstop10h 35mAir Europa
Deal found 4/11RM 3,445
Tue 31/320:25PTY - MAD
Nonstop9h 50mAir Europa
Tue 14/415:05MAD - PTY
Nonstop10h 35mAir Europa
Deal found 3/11RM 3,454
Fri 30/121:30PTY - MAD
Nonstop9h 35mAir Europa
Wed 25/215:10MAD - PTY
Nonstop10h 35mAir Europa
Deal found 4/11RM 3,466
Sat 14/221:30PTY - MAD
Nonstop9h 35mAir Europa
Wed 4/315:10MAD - PTY
Nonstop10h 35mAir Europa
Deal found 3/11RM 3,471
Mon 30/320:25PTY - MAD
Nonstop9h 50mAir Europa
Sat 18/415:05MAD - PTY
Nonstop10h 35mAir Europa
Deal found 4/11RM 3,580

Find direct flights from Panama City within your budget

 
Use the slider to find direct flights from Panama City within your budget. Price data is based on user searches made on Cheapflights. Over the past seven days, Cheapflights users made 407,431 searches. This data was last updated on 5 November 2025.

Fly to

Kuala Lumpur Intl

Route

Departure

Return

Price

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Mon 20/4

20:25-13:15

Nonstop9h 50m

Madrid Barajas

Thu 30/4

15:05-18:40

Nonstop10h 35m

RM 3,042

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Mon 20/4

20:25-13:15

Nonstop9h 50m

Madrid Barajas

Sun 26/4

15:05-18:40

Nonstop10h 35m

RM 3,042

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Sun 26/4

20:25-13:15

Nonstop9h 50m

Madrid Barajas

Fri 1/5

15:05-18:40

Nonstop10h 35m

RM 3,042

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Sat 25/4

20:25-13:15

Nonstop9h 50m

Madrid Barajas

Thu 30/4

15:05-18:40

Nonstop10h 35m

RM 3,042

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Sun 26/4

20:25-13:15

Nonstop9h 50m

Madrid Barajas

Thu 30/4

15:05-18:40

Nonstop10h 35m

RM 3,042

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Fri 1/5

20:25-13:15

Nonstop9h 50m

Madrid Barajas

Wed 20/5

15:05-18:40

Nonstop10h 35m

RM 3,042

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Fri 1/5

20:25-13:15

Nonstop9h 50m

Madrid Barajas

Thu 21/5

15:05-18:40

Nonstop10h 35m

RM 3,042

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Thu 30/4

20:25-13:15

Nonstop9h 50m

Madrid Barajas

Mon 25/5

15:05-18:40

Nonstop10h 35m

RM 3,177

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Thu 30/4

20:25-13:15

Nonstop9h 50m

Madrid Barajas

Thu 21/5

15:05-18:40

Nonstop10h 35m

RM 3,177

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Sun 8/3

21:30-13:05

Nonstop9h 35m

Madrid Barajas

Fri 13/3

15:10-19:45

Nonstop10h 35m

RM 3,177

Flights are sorted by cheapest return flights first.

Deals found on 4/11

Showing 1-10 of 22 results
1
2
3

Best time to book a flight from Panama City

Have a flexible travel schedule? Discover the best time to fly from Panama City with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Access useful and relevant information related to your journey from Panama City. This can include details such as airport transportation, visa requirements, travel insurance, luggage regulations, and any other information that can ensure a smooth and hassle-free travel experience. Please note that the information is based on general guidance and may need to be verified with official sources. Data last updated 5 November 2025.

  • Where can you fly direct from Panama City?

    Currently, the most popular direct flight destination from Panama City is Montego Bay.

  • What is the best time of year to fly direct from Panama City?

    If you're seeking the lowest price on a direct flight from Panama City, March is worth consideration as prices are at their lowest, on average. In terms of the number of daily non-stop flights, March offers travelers the most options.

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Direct flights from cities

Book a direc flight from one of these other cities located in .
Direct flights from Panama City

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.