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RM 2,394+ Direct flights from Panama City

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 15/10. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
PTY — KUL
16 Oct — 23 Oct1
1 adult
1 adult, Economy

Direct flights from Panama City

Cheapest flights from Panama City
Explore the most affordable flight options available from Panama City. Find the lowest fares based on data from user searches, with prices last updated on 16 September 2025.

Sun 2/1121:30PTY - MAD
Nonstop9h 35mAir Europa
Fri 14/1115:10MAD - PTY
Nonstop10h 35mAir Europa
Deal found 15/9RM 2,894
Mon 3/1121:30PTY - MAD
Nonstop9h 35mAir Europa
Sun 23/1115:10MAD - PTY
Nonstop10h 35mAir Europa
Deal found 15/9RM 2,899
Sun 18/121:30PTY - MAD
Nonstop9h 35mAir Europa
Sun 25/115:10MAD - PTY
Nonstop10h 35mAir Europa
Deal found 15/9RM 2,915
Thu 30/1021:30PTY - MAD
Nonstop9h 35mAir Europa
Fri 14/1115:10MAD - PTY
Nonstop10h 35mAir Europa
Deal found 15/9RM 3,029
Mon 6/1017:10PTY - MAD
Nonstop10h 05mIberia
Tue 14/1012:00MAD - PTY
Nonstop10h 40mIberia
Deal found 14/9RM 3,046
Sun 18/121:30PTY - MAD
Nonstop9h 35mAir Europa
Sun 1/215:10MAD - PTY
Nonstop10h 35mAir Europa
Deal found 15/9RM 3,050
Mon 13/1017:10PTY - MAD
Nonstop10h 05mIberia
Tue 30/612:00MAD - PTY
Nonstop11h 05mIberia
Deal found 15/9RM 3,180
Wed 17/1221:30PTY - MAD
Nonstop9h 35mAir Europa
Sun 18/115:10MAD - PTY
Nonstop10h 35mAir Europa
Deal found 15/9RM 3,184
Sun 2/1121:30PTY - MAD
Nonstop9h 35mAir Europa
Thu 13/1115:10MAD - PTY
Nonstop10h 35mAir Europa
Deal found 15/9RM 3,277
Tue 14/1020:25PTY - MAD
Nonstop9h 50mAir Europa
Fri 31/1015:10MAD - PTY
Nonstop10h 35mAir Europa
Deal found 14/9RM 3,285
Thu 30/1021:30PTY - MAD
Nonstop9h 35mAir Europa
Fri 7/1115:10MAD - PTY
Nonstop10h 35mAir Europa
Deal found 15/9RM 3,411

Find direct flights from Panama City within your budget

 
Use the slider to find direct flights from Panama City within your budget. Price data is based on user searches made on Cheapflights. Over the past seven days, Cheapflights users made 407,431 searches. This data was last updated on 16 September 2025.

Fly to

Kuala Lumpur Intl

Route

Departure

Return

Price

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Mon 3/11

21:30-13:05

Nonstop9h 35m

Madrid Barajas

Fri 14/11

15:10-19:45

Nonstop10h 35m

RM 2,894

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Tue 4/11

21:30-13:05

Nonstop9h 35m

Madrid Barajas

Sun 16/11

15:10-19:45

Nonstop10h 35m

RM 2,894

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Tue 18/11

21:30-13:05

Nonstop9h 35m

Madrid Barajas

Sun 23/11

15:10-19:45

Nonstop10h 35m

RM 2,894

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Tue 4/11

21:30-13:05

Nonstop9h 35m

Madrid Barajas

Fri 14/11

15:10-19:45

Nonstop10h 35m

RM 2,894

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Mon 17/11

21:30-13:05

Nonstop9h 35m

Madrid Barajas

Sun 23/11

15:10-19:45

Nonstop10h 35m

RM 2,894

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Mon 3/11

21:30-13:05

Nonstop9h 35m

Madrid Barajas

Sun 16/11

15:10-19:45

Nonstop10h 35m

RM 2,894

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Tue 4/11

21:30-13:05

Nonstop9h 35m

Madrid Barajas

Mon 17/11

15:10-19:45

Nonstop10h 35m

RM 2,894

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Sat 31/1

21:30-13:05

Nonstop9h 35m

Madrid Barajas

Tue 3/3

15:10-19:45

Nonstop10h 35m

RM 2,915

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Sat 7/2

21:30-13:05

Nonstop9h 35m

Madrid Barajas

Wed 18/2

15:10-19:45

Nonstop10h 35m

RM 2,915

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Fri 6/2

21:30-13:05

Nonstop9h 35m

Madrid Barajas

Wed 18/2

15:10-19:45

Nonstop10h 35m

RM 2,915

Flights are sorted by cheapest return flights first.

Deals found on 13/9

Showing 1-10 of 21 results
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Best time to book a flight from Panama City

Have a flexible travel schedule? Discover the best time to fly from Panama City with our price prediction graph.
Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Access useful and relevant information related to your journey from Panama City. This can include details such as airport transportation, visa requirements, travel insurance, luggage regulations, and any other information that can ensure a smooth and hassle-free travel experience. Please note that the information is based on general guidance and may need to be verified with official sources. Data last updated 16 September 2025.

  • Where can you fly direct from Panama City?

    Currently, the most popular direct flight destination from Panama City is Montego Bay.

  • What is the best time of year to fly direct from Panama City?

    If you're seeking the lowest price on a direct flight from Panama City, March is worth consideration as prices are at their lowest, on average. In terms of the number of daily non-stop flights, March offers travelers the most options.

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