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RM 2,441+ Direct flights from Panama City

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/4. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
PTY — KUL
6 Apr — 13 Apr1
1 adult
1 adult, Economy, 0 bags

Direct flights from Panama City

Enter your travel dates to find the best prices.

Cheapest flights from Panama City
Explore the most affordable flight options available from Panama City. Find the lowest fares based on data from user searches, with prices last updated on 7 March 2026.

Wed 22/420:25
PTY
-
MAD
Nonstop9h 50m
Air Europa
Wed 29/415:05
MAD
-
PTY
Nonstop10h 35m
Air Europa
Deal found 4/3RM 2,717
Mon 18/520:25
PTY
-
MAD
Nonstop9h 50m
Air Europa
Wed 27/515:05
MAD
-
PTY
Nonstop10h 35m
Air Europa
Deal found 3/3RM 2,761
Wed 27/520:25
PTY
-
MAD
Nonstop9h 50m
Air Europa
Fri 12/615:05
MAD
-
PTY
Nonstop10h 35m
Air Europa
Deal found 4/3RM 2,844
Mon 27/420:25
PTY
-
MAD
Nonstop9h 50m
Air Europa
Fri 22/515:05
MAD
-
PTY
Nonstop10h 35m
Air Europa
Deal found 3/3RM 2,847
Tue 2/620:25
PTY
-
MAD
Nonstop9h 50m
Air Europa
Thu 11/615:05
MAD
-
PTY
Nonstop10h 35m
Air Europa
Deal found 2/3RM 2,867
Sun 19/420:25
PTY
-
MAD
Nonstop9h 50m
Air Europa
Mon 27/415:05
MAD
-
PTY
Nonstop10h 35m
Air Europa
Deal found 6/3RM 2,883
Tue 28/420:25
PTY
-
MAD
Nonstop9h 50m
Air Europa
Sat 16/515:05
MAD
-
PTY
Nonstop10h 35m
Air Europa
Deal found 6/3RM 2,887
Mon 27/420:25
PTY
-
MAD
Nonstop9h 50m
Air Europa
Sat 16/515:05
MAD
-
PTY
Nonstop10h 35m
Air Europa
Deal found 2/3RM 2,911
Sun 10/520:25
PTY
-
MAD
Nonstop9h 50m
Air Europa
Sat 16/515:05
MAD
-
PTY
Nonstop10h 35m
Air Europa
Deal found 7/3RM 2,926
Sun 31/520:25
PTY
-
MAD
Nonstop9h 50m
Air Europa
Thu 11/615:05
MAD
-
PTY
Nonstop10h 35m
Air Europa
Deal found 4/3RM 2,974
Wed 6/520:25
PTY
-
MAD
Nonstop9h 50m
Air Europa
Sun 7/615:05
MAD
-
PTY
Nonstop10h 35m
Air Europa
Deal found 3/3RM 2,993

Find direct flights from Panama City within your budget

 
Use the slider to find direct flights from Panama City within your budget. Price data is based on user searches made on Cheapflights. Over the past seven days, Cheapflights users made 407,431 searches. This data was last updated on 7 March 2026.

Fly to

Route

Departure

Return

Price

Cheapest return flight
Fastest return journey

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Mon 27/4

20:25-13:15

Nonstop9h 50m

Madrid Barajas

Mon 11/5

15:05-18:40

Nonstop10h 35m

RM 2,847

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Tue 2/6

20:25-13:15

Nonstop9h 50m

Madrid Barajas

Thu 11/6

15:05-18:40

Nonstop10h 35m

RM 2,867

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Wed 20/5

21:30-14:20

Nonstop9h 50m

Madrid Barajas

Wed 3/6

15:55-20:00

Nonstop11h 05m

RM 2,993

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Mon 1/6

20:25-13:15

Nonstop9h 50m

Madrid Barajas

Wed 10/6

15:05-18:40

Nonstop10h 35m

RM 2,993

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Mon 4/5

20:25-13:15

Nonstop9h 50m

Madrid Barajas

Wed 6/5

15:05-18:40

Nonstop10h 35m

RM 3,013

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Sun 3/5

21:30-14:20

Nonstop9h 50m

Madrid Barajas

Sun 24/5

15:55-20:00

Nonstop11h 05m

RM 3,076

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Thu 2/4

20:25-13:15

Nonstop9h 50m

Madrid Barajas

Sun 12/4

15:05-18:40

Nonstop10h 35m

RM 3,368

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Tue 18/8

20:25-13:15

Nonstop9h 50m

Madrid Barajas

Tue 8/9

15:05-18:40

Nonstop10h 35m

RM 3,459

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Mon 17/8

20:25-13:15

Nonstop9h 50m

Madrid Barajas

Thu 10/9

15:05-18:40

Nonstop10h 35m

RM 3,459

Panama CityMadrid

PTY - MAD

PTYMAD

Panama City Tocumen Intl

Tue 14/4

20:25-13:15

Nonstop9h 50m

Madrid Barajas

Wed 29/4

15:05-18:40

Nonstop10h 35m

RM 3,494

Flights are sorted by cheapest return flights first.

Deals found on 2/3

Showing 1-10 of 23 resultsSorted by cheapest first
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Estimated return price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

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