RM 2,394+ Direct flights from Panama City
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 15/10. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
Direct flights from Panama City
Cheapest flights from Panama CityExplore the most affordable flight options available from Panama City. Find the lowest fares based on data from user searches, with prices last updated on 16 September 2025.
Explore the most affordable flight options available from Panama City. Find the lowest fares based on data from user searches, with prices last updated on 16 September 2025.
Find direct flights from Panama City within your budget
Fly to
Route
Departure
Return
Price
Panama CityMadrid
PTY - MAD
PTYMAD
Panama City Tocumen Intl
Mon 3/11
21:30-13:05
Nonstop9h 35m
Madrid Barajas
Fri 14/11
15:10-19:45
Nonstop10h 35m
Panama CityMadrid
PTY - MAD
PTYMAD
Panama City Tocumen Intl
Tue 4/11
21:30-13:05
Nonstop9h 35m
Madrid Barajas
Sun 16/11
15:10-19:45
Nonstop10h 35m
Panama CityMadrid
PTY - MAD
PTYMAD
Panama City Tocumen Intl
Tue 18/11
21:30-13:05
Nonstop9h 35m
Madrid Barajas
Sun 23/11
15:10-19:45
Nonstop10h 35m
Panama CityMadrid
PTY - MAD
PTYMAD
Panama City Tocumen Intl
Tue 4/11
21:30-13:05
Nonstop9h 35m
Madrid Barajas
Fri 14/11
15:10-19:45
Nonstop10h 35m
Panama CityMadrid
PTY - MAD
PTYMAD
Panama City Tocumen Intl
Mon 17/11
21:30-13:05
Nonstop9h 35m
Madrid Barajas
Sun 23/11
15:10-19:45
Nonstop10h 35m
Panama CityMadrid
PTY - MAD
PTYMAD
Panama City Tocumen Intl
Mon 3/11
21:30-13:05
Nonstop9h 35m
Madrid Barajas
Sun 16/11
15:10-19:45
Nonstop10h 35m
Panama CityMadrid
PTY - MAD
PTYMAD
Panama City Tocumen Intl
Tue 4/11
21:30-13:05
Nonstop9h 35m
Madrid Barajas
Mon 17/11
15:10-19:45
Nonstop10h 35m
Panama CityMadrid
PTY - MAD
PTYMAD
Panama City Tocumen Intl
Sat 31/1
21:30-13:05
Nonstop9h 35m
Madrid Barajas
Tue 3/3
15:10-19:45
Nonstop10h 35m
Panama CityMadrid
PTY - MAD
PTYMAD
Panama City Tocumen Intl
Sat 7/2
21:30-13:05
Nonstop9h 35m
Madrid Barajas
Wed 18/2
15:10-19:45
Nonstop10h 35m
Panama CityMadrid
PTY - MAD
PTYMAD
Panama City Tocumen Intl
Fri 6/2
21:30-13:05
Nonstop9h 35m
Madrid Barajas
Wed 18/2
15:10-19:45
Nonstop10h 35m